Fetal calf serum inhibits virus genome expression in Madin-Darby canine kidney cells persistently infected with influenza A virus
Identifieur interne : 001436 ( Main/Exploration ); précédent : 001435; suivant : 001437Fetal calf serum inhibits virus genome expression in Madin-Darby canine kidney cells persistently infected with influenza A virus
Auteurs : Md. Jaber Hossain [Japon] ; Isamu Mori [Japon] ; Li Dong [Japon] ; Beixing Liu [Japon] ; Yoshinobu Kimura [Japon]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 2008-03-01.
English descriptors
Abstract
Abstract: A cell line of Madin-Darby canine kidney (MDCK) cells persistently infected with human influenza A virus has been established and designated as MDCK-IVpi cells. Production of progeny virus in MDCK-IVpi cells was suppressed when the cells were incubated in the presence of 10% fetal calf serum (FCS). FCS impaired virus mRNA synthesis in MDCK-IVpi cells, which resulted in a scarcity of virus proteins for virion formation. However, MDCK-IVpi cells well supported the growth of superinfecting heterologous influenza viruses, even in the presence of FCS. A certain fetuin-like substance in FCS might be responsible for the observed inhibition of virus replication.
Url:
DOI: 10.1007/s00430-007-0054-1
Affiliations:
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Jaber Hossain</name></noRegion><name sortKey="Dong, Li" sort="Dong, Li" uniqKey="Dong L" first="Li" last="Dong">Li Dong</name><name sortKey="Kimura, Yoshinobu" sort="Kimura, Yoshinobu" uniqKey="Kimura Y" first="Yoshinobu" last="Kimura">Yoshinobu Kimura</name><name sortKey="Kimura, Yoshinobu" sort="Kimura, Yoshinobu" uniqKey="Kimura Y" first="Yoshinobu" last="Kimura">Yoshinobu Kimura</name><name sortKey="Kimura, Yoshinobu" sort="Kimura, Yoshinobu" uniqKey="Kimura Y" first="Yoshinobu" last="Kimura">Yoshinobu Kimura</name><name sortKey="Liu, Beixing" sort="Liu, Beixing" uniqKey="Liu B" first="Beixing" last="Liu">Beixing Liu</name><name sortKey="Mori, Isamu" sort="Mori, Isamu" uniqKey="Mori I" first="Isamu" last="Mori">Isamu Mori</name><name sortKey="Mori, Isamu" sort="Mori, Isamu" uniqKey="Mori I" first="Isamu" last="Mori">Isamu Mori</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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